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•  【New!】終末糖化産物と運動能力低下： 老化の新たな視点

Advanced Glycation End Products and Mobility Decline: A Novel Perspective on Aging - PubMed

• 統合失調症とAGEs蓄積の関係

Skin advanced glycation end products, indicating cumulative oxidative stress, associated with schizophrenia but not with psychosis-like experiences

• 坐骨・抹消神経障害と終末糖化産物の関係

Intradermal Advanced Glycation End-products Relate to Reduced Sciatic Nerve Structural Integrity in Type 2 Diabetes | Clinical Neuroradiology

• 終末糖化産物と客観的な肌質パラメータとの関係

The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters

• IB-4ではなく、Forns指数と脂肪肝指数は、血糖値、糖尿病前症および2型糖尿病の指標と関連する

Forns index and fatty liver index, but not FIB-4, are associated with indices of glycaemia, pre-diabetes and type 2 diabetes: analysis of The Maastricht Study - PMC

• AGEsとメタボロミクスはフレイルと関係している

Advanced glycation end-products and metabolomics are independently associated with frailty: the longitudinal Doetinchem Cohort Study

• AGEsと微小・大血管合併症との関連

Association Between the Tissue and Circulating Advanced Glycation End-Products and the Micro- and Macrovascular Complications in Type 1 Diabetes: The DIABAGE Study

• 2型糖尿病男性患者における血清テストステロン濃度と皮膚自発蛍光の冠動脈疾患リスクマーカーとしての有用性

Usefulness of Serum Testosterone Concentration and Skin Autofluorescence as Coronary Risk Markers in Male Patients With Type 2 Diabetes Mellitus

• 若年集団におけるAGEs蓄積と血管内皮機能の関係

Association between endothelial function and skin advanced glycation end-products (AGEs) accumulation in a sample of predominantly young and healthy adults - PMC

• AGEs蓄積と冠動脈石灰化の関係

Association between skin autofluorescence and coronary calcification in the general population - PMC

• 睡眠時間と心血管疾患リスクとの関係

 Association between sleep duration and cardiovascular risk: the EVasCu cross-sectional study - PMC (nih.gov)

• AGEsと高齢者における転倒リスクの関係

Accumulation of advanced glycation end products in skin and increased vascular ageing in the general population: the Malmö Offspring Study - PMC (nih.gov)

• 高度肥満は皮膚のAGEsを増加させる

 Morbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components - PMC (nih.gov)

• うつ病を発症するリウマチ患者と、発症しないリウマチ患者における皮膚中AGEsの比較

Comparison of advanced glycation end products concentration in the skin among patients with rheumatic diseases with and without comorbid depression: a case-control study

• 一般集団における

A non-invasive risk score including skin autofluorescence predicts diabetes risk in the general population 

• 小児期と青年期１型糖尿病患者における皮膚自家蛍光測定：寛解の予測因子としての可能性

The Bright Side of Skin Autofluorescence Determination in Children and Adolescents with Newly Diagnosed Type 1 diabetes Mellitus: A Potential Predictor of Remission?

• AGEと肝繊維化の関係

Skin Autofluorescence Measurement as Initial Assessment of Hepatic Parenchyma Quality  in  Patients  Undergoing Liver Resection

• AGEは糖尿病患者においてガンを予測する

Skin autofluorescence predicts cancer in subjects with type 2 diabetes | BMJ Open Diabetes Research & Care: Open Diab Res Care 2021;9:e001312. doi:10.1136/ bmjdrc-2020-001312

• AGEsとビタミンDの関係

Vitamin D status is associated with skin autofluorescence in patients with type 2 diabetes mellitus: a preliminary report - PubMed (nih.gov)

• AGEsとHbA1cの関係    

Skin autofluorescence is associated with past glycaemic control and complications in type 1 diabetes mellitus - ScienceDirect

• 食品中AGEｓと皮膚AGEｓの関係

The association between dietary and skin advanced glycation end products: the Rotterdam Study | The American Journal of Clinical Nutrition | Oxford Academic (oup.com)

• AGEsとサルコペニアの関係

Skin autofluorescence, a non-invasive biomarker for advanced glycation end-products, is associated with Sarcopenia - PubMed (nih.gov)

• 皮膚AGEsと糖尿病性神経障害の関係 

Skin AGEs and diabetic neuropathy | BMC Endocrine Disorders | Full Text (biomedcentral.com)

• 食事中AGEsと皮膚・尿中AGEの関係 

Dietary Advanced Glycation End Products in an Elderly Population with Diabetic Nephropathy: An Exploratory Investigation - PMC (nih.gov)

• AGEsとフレイルの関係 

Skin autofluorescence, a non-invasive biomarker of advanced glycation end-products (AGEs), is associated with frailty: The Rotterdam study - PubMed (nih.gov)

• Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus.  Lutgers H. et al, Diabetologia, 2009; 52(5): 789-797

• Skin autofluorescence and risk of micro- and macrovascular complications in patients with Type 2 diabetes mellitus-a multi-centre study. Noordzij M.J. et al. Diabet Med. 2012 Dec;29(12):1556-61.

• Skin Autofluorescence: A tool to identify type 2 diabetic patients at risk for developing microvascular disease. Gerrits E. et al. Diabetes Care. 2008; 31: 517-521

• Skin Autofluorescence – A Non-invasive Measurement for Assessing Cardiovascular Risk and Risk of Diabetes. A. Stirban & L. Heinemann European Endocrinology, 2014;10(2):106–10. Full text available.

• Skin Autofluorescence Is Associated With 5-Year Mortality and Cardiovascular Events in Patients With Peripheral Artery Disease. de Vos LC. et al. Arterioscler Thromb Vasc Biol. 2014 Feb 13.

• Skin Autofluorescence and the Association with Renal and Cardiovascular Risk Factors in Chronic Kidney Disease Stage 3. McIntyre N. et al. Clin J Am Soc Nephrol. 2011 Sep 1. Epub

• Skin-Autofluorescence Is an Independent Predictor of Graft Loss in Renal Transplant Recipients. Hartog J. et al. Transplantation, Volume 87, Number 7, April 15, 2009.

• Simple non-invasive assessment of advanced glycation endproducts accumulation. Meerwaldt R et al, Diabetologia, 2004; 47:1324-1330

• 1. Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study. Schweitzer C. et al. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):75-84.
  2. Association of advanced glycation end products, evaluated by skin autofluorescence, with lifestyle habits in a general Japanese population. Isami  et al. J Int Med Res. 2018 Jan 1:300060517736914. doi:10.1177/0300060517736914.
  3. Skin Autofluorescence is a Noninvasive Surrogate Marker for Diabetic Microvascular Complications and Carotid Intima-Media Thickness in Japanese Patients with Type 2 Diabetes: A Cross-sectional Study. Yoshioka K. Diabetes Ther. 2017 Nov 24. doi: 10.1007/s13300-017-0339-3.
  4. Skin autofluorescence improves the Finnish Diabetes Risk Score in the detection of diabetes in a large population-based cohort: The LifeLines Cohort Study. Fokkens B.T. et al. Diabetes Metab. 2017 Oct 30. pii: S1262-3636(17)30513-X. doi: 10.1016/j.diabet.2017.09.002.
  5. Association Between Accumulation of Advanced Glycation End-Products and Hearing Impairment in Community-Dwelling Older People: A Cross-Sectional Sukagawa Study. Niihata K. et al. J Am Med Dir Assoc. 2017 Nov 1. pii: S1525-8610(17)30520-0. doi: 10.1016/j.jamda.2017.09.008.
  6. Accumulation of advanced glycation end products evaluated by skin autofluorescence and incident frailty in older adults from the Bordeaux Three-City cohort. Pilleron S. et al. PLoS One. 2017 Oct 17;12(10):e0186087.
  7. Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus. Ahmad M.S. et al. PLoS One. 2017 Sep 20;12(9):e0185175.
  8. Advanced glycation end-products (AGEs) accumulation in skin: relations with chronic kidney disease-mineral and bone disorder. França R.A. et al. J Bras Nefrol. 2017 Jul-Sep;39(3):253-260.
  9. Progression of skin autofluorescence of AGEs over 4 years in patients with type 1 diabetes. Rajaobelina K et al. Diabetes Metab Res Rev. 2017 Oct;33(7). doi: 10.1002/dmrr.2917.
  10. Association between habitual dietary and lifestyle behaviours and skin autofluorescence (SAF), a marker of tissue accumulation of advanced glycation endproducts (AGEs), in healthy adults. Kellow N.J. et al. Eur J Nutr. 2017 Jun 27. doi: 10.1007/s00394-017-1495-y. .
  11. Skin accumulation of advanced glycation end products is increased in patients with an abdominal aortic aneurysm. Boersema J et al. J Vasc Surg. 2017 Dec;66(6):1696-1703.e1. doi: 10.1016/j.jvs.2017.04.037.
  12. The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation. van Waateringe R.P. et al. PLoS One. 2017 Jun 20;12(6):e0179330.
  13. Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components. van Waateringe R.P. et al.  Diabetol Metab Syndr. 2017 May 30;9:42.
  14. Re: Skin Autofluorescence (a Marker for Advanced Glycation End Products) and Erectile Dysfunction in Diabetes. Seftel A.D. et al. J Urol. 2017 Jun;197(6):1533-1535
  15. Advanced Glycation End Products in Recent-Onset Psychosis Indicate Early Onset of Cardiovascular Risk. Hagen J.M. et al. J Clin Psychiatry. 2017 Apr 25. doi: 10.4088/JCP.16m10972.
  16. The relationship between circulating irisin levels and tissues AGE accumulation in type 2 diabetes patients. Li Z. et al. Biosci Rep. 2017 Jun 8;37(3).
  17. Diverging effects of diabetes mellitus in patients with peripheral artery disease and abdominal aortic aneurysm and the role of advanced glycation end-products: ARTERY study – protocol for a multicentre cross-sectional study. de Vos L.C. et al. BMJ Open. 2017 Apr 11;7(4):e012584.
  18. Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls. Fokkens B.T. et al. PLoS One. 2017 Mar 6;12(3):e0173379.
  19. Advanced glycation end-products (AGEs) and associations with cardio-metabolic, lifestyle, and dietary factors in a general population: the NQplus study. Botros N. et al. Diabetes Metab Res Rev. 2017 Jul;33(5).
  20. Skin autofluorescence is associated with arterial stiffness and insulin level in endurance runners and healthy controls – Effects of aging and endurance exercise. Couppé C. et al. Exp Gerontol. 2017 May;91:9-14.
  21. Skin autofluorescence, a non-invasive marker of advanced glycation end products: clinical relevance and limitations. Da Moura Semedo C. et al. Postgrad Med J. 2017 May;93(1099):289-294.
  22. Skin autofluorescence, renal insufficiency and retinopathy in patients with type 2 diabetes. Bentata R. et al. J Diabetes Complications. 2017 Mar;31(3):619-623.
  23. The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma. Himori N. et al. Br J Ophthalmol. 2017 Feb;101(2):233-238.
  24. Risk factors for autonomic and somatic nerve dysfunction in different stages of glucose tolerance. Dimova R. et al. J Diabetes Complications. 2017 Mar;31(3):537-543.
  25. Skin autofluorescence is increased in young people with type 1 diabetes exposed to second hand smoking. Vollenbrock C.E. et al. J Diabetes. 2017 Mar;9(3):308-310.
  26. Higher skin autofluorescence in young people with Type 1 diabetes and microvascular complications. Cho Y.H. et al. Diabet Med. 2017 Apr;34(4):543-550.
  27. Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes. Mori H. et al. J Diabetes Investig. 2017 May;8(3):377-382.
  28. Skin Autofluorescence is Associated with Early-stage Atherosclerosis in Patients with Type 1 Diabetes. Osawa S. et al. J Atheroscler Thromb. 2017 Mar 1;24(3):312-326.
  29. Skin autofluorescence and peripheral neuropathy four years later in type 1 diabetes. Rajaobelina K. et al. Diabetes Metab Res Rev. 2017 Feb;33(2).
  30. Relationship between advanced glycation end-product accumulation and low skeletal muscle mass in Japanese men and women. Kato M. et al. Geriatr Gerontol Int. 2017 May;17(5):785-790.