各分野においてAGE Readerを用いた多くの論文が発表されています。

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• AGEは糖尿病患者においてガンを予測する

Skin autofluorescence predicts cancer in subjects with type 2 diabetes | BMJ Open Diabetes Research & Care: Open Diab Res Care 2021;9:e001312. doi:10.1136/ bmjdrc-2020-001312

• AGEsとビタミンDの関係

Vitamin D status is associated with skin autofluorescence in patients with type 2 diabetes mellitus: a preliminary report - PubMed (nih.gov)

• AGEsとHbA1cの関係    

 Skin autofluorescence is associated with past glycaemic control and complications in type 1 diabetes mellitus - ScienceDirect

• 食品中AGEｓと皮膚AGEｓの関係　 

association between dietary and skin advanced glycation end products: the Rotterdam Study | The American Journal of Clinical Nutrition | Oxford Academic (oup.com)

• AGEsとサルコペニアの関係

Skin autofluorescence, a non-invasive biomarker for advanced glycation end-products, is associated with Sarcopenia - PubMed (nih.gov)

• 皮膚AGEsと糖尿病性神経障害の関係 New!

Skin AGEs and diabetic neuropathy | BMC Endocrine Disorders | Full Text (biomedcentral.com)

• Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus.  Lutgers H. et al, Diabetologia, 2009; 52(5): 789-797

• Skin autofluorescence and risk of micro- and macrovascular complications in patients with Type 2 diabetes mellitus-a multi-centre study. Noordzij M.J. et al. Diabet Med. 2012 Dec;29(12):1556-61.

• Skin Autofluorescence: A tool to identify type 2 diabetic patients at risk for developing microvascular disease. Gerrits E. et al. Diabetes Care. 2008; 31: 517-521

• Skin Autofluorescence – A Non-invasive Measurement for Assessing Cardiovascular Risk and Risk of Diabetes. A. Stirban & L. Heinemann European Endocrinology, 2014;10(2):106–10. Full text available.

• Skin Autofluorescence Is Associated With 5-Year Mortality and Cardiovascular Events in Patients With Peripheral Artery Disease. de Vos LC. et al. Arterioscler Thromb Vasc Biol. 2014 Feb 13.

• Skin Autofluorescence and the Association with Renal and Cardiovascular Risk Factors in Chronic Kidney Disease Stage 3. McIntyre N. et al. Clin J Am Soc Nephrol. 2011 Sep 1. Epub

• Skin-Autofluorescence Is an Independent Predictor of Graft Loss in Renal Transplant Recipients. Hartog J. et al. Transplantation, Volume 87, Number 7, April 15, 2009.

• Simple non-invasive assessment of advanced glycation endproducts accumulation. Meerwaldt R et al, Diabetologia, 2004; 47:1324-1330

• 1. Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study. Schweitzer C. et al. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):75-84.
  2. Association of advanced glycation end products, evaluated by skin autofluorescence, with lifestyle habits in a general Japanese population. Isami  et al. J Int Med Res. 2018 Jan 1:300060517736914. doi:10.1177/0300060517736914.
  3. Skin Autofluorescence is a Noninvasive Surrogate Marker for Diabetic Microvascular Complications and Carotid Intima-Media Thickness in Japanese Patients with Type 2 Diabetes: A Cross-sectional Study. Yoshioka K. Diabetes Ther. 2017 Nov 24. doi: 10.1007/s13300-017-0339-3.
  4. Skin autofluorescence improves the Finnish Diabetes Risk Score in the detection of diabetes in a large population-based cohort: The LifeLines Cohort Study. Fokkens B.T. et al. Diabetes Metab. 2017 Oct 30. pii: S1262-3636(17)30513-X. doi: 10.1016/j.diabet.2017.09.002.
  5. Association Between Accumulation of Advanced Glycation End-Products and Hearing Impairment in Community-Dwelling Older People: A Cross-Sectional Sukagawa Study. Niihata K. et al. J Am Med Dir Assoc. 2017 Nov 1. pii: S1525-8610(17)30520-0. doi: 10.1016/j.jamda.2017.09.008.
  6. Accumulation of advanced glycation end products evaluated by skin autofluorescence and incident frailty in older adults from the Bordeaux Three-City cohort. Pilleron S. et al. PLoS One. 2017 Oct 17;12(10):e0186087.
  7. Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus. Ahmad M.S. et al. PLoS One. 2017 Sep 20;12(9):e0185175.
  8. Advanced glycation end-products (AGEs) accumulation in skin: relations with chronic kidney disease-mineral and bone disorder. França R.A. et al. J Bras Nefrol. 2017 Jul-Sep;39(3):253-260.
  9. Progression of skin autofluorescence of AGEs over 4 years in patients with type 1 diabetes. Rajaobelina K et al. Diabetes Metab Res Rev. 2017 Oct;33(7). doi: 10.1002/dmrr.2917.
  10. Association between habitual dietary and lifestyle behaviours and skin autofluorescence (SAF), a marker of tissue accumulation of advanced glycation endproducts (AGEs), in healthy adults. Kellow N.J. et al. Eur J Nutr. 2017 Jun 27. doi: 10.1007/s00394-017-1495-y. .
  11. Skin accumulation of advanced glycation end products is increased in patients with an abdominal aortic aneurysm. Boersema J et al. J Vasc Surg. 2017 Dec;66(6):1696-1703.e1. doi: 10.1016/j.jvs.2017.04.037.
  12. The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation. van Waateringe R.P. et al. PLoS One. 2017 Jun 20;12(6):e0179330.
  13. Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components. van Waateringe R.P. et al.  Diabetol Metab Syndr. 2017 May 30;9:42.
  14. Re: Skin Autofluorescence (a Marker for Advanced Glycation End Products) and Erectile Dysfunction in Diabetes. Seftel A.D. et al. J Urol. 2017 Jun;197(6):1533-1535
  15. Advanced Glycation End Products in Recent-Onset Psychosis Indicate Early Onset of Cardiovascular Risk. Hagen J.M. et al. J Clin Psychiatry. 2017 Apr 25. doi: 10.4088/JCP.16m10972.
  16. The relationship between circulating irisin levels and tissues AGE accumulation in type 2 diabetes patients. Li Z. et al. Biosci Rep. 2017 Jun 8;37(3).
  17. Diverging effects of diabetes mellitus in patients with peripheral artery disease and abdominal aortic aneurysm and the role of advanced glycation end-products: ARTERY study – protocol for a multicentre cross-sectional study. de Vos L.C. et al. BMJ Open. 2017 Apr 11;7(4):e012584.
  18. Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls. Fokkens B.T. et al. PLoS One. 2017 Mar 6;12(3):e0173379.
  19. Advanced glycation end-products (AGEs) and associations with cardio-metabolic, lifestyle, and dietary factors in a general population: the NQplus study. Botros N. et al. Diabetes Metab Res Rev. 2017 Jul;33(5).
  20. Skin autofluorescence is associated with arterial stiffness and insulin level in endurance runners and healthy controls – Effects of aging and endurance exercise. Couppé C. et al. Exp Gerontol. 2017 May;91:9-14.
  21. Skin autofluorescence, a non-invasive marker of advanced glycation end products: clinical relevance and limitations. Da Moura Semedo C. et al. Postgrad Med J. 2017 May;93(1099):289-294.
  22. Skin autofluorescence, renal insufficiency and retinopathy in patients with type 2 diabetes. Bentata R. et al. J Diabetes Complications. 2017 Mar;31(3):619-623.
  23. The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma. Himori N. et al. Br J Ophthalmol. 2017 Feb;101(2):233-238.
  24. Risk factors for autonomic and somatic nerve dysfunction in different stages of glucose tolerance. Dimova R. et al. J Diabetes Complications. 2017 Mar;31(3):537-543.
  25. Skin autofluorescence is increased in young people with type 1 diabetes exposed to second hand smoking. Vollenbrock C.E. et al. J Diabetes. 2017 Mar;9(3):308-310.
  26. Higher skin autofluorescence in young people with Type 1 diabetes and microvascular complications. Cho Y.H. et al. Diabet Med. 2017 Apr;34(4):543-550.
  27. Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes. Mori H. et al. J Diabetes Investig. 2017 May;8(3):377-382.
  28. Skin Autofluorescence is Associated with Early-stage Atherosclerosis in Patients with Type 1 Diabetes. Osawa S. et al. J Atheroscler Thromb. 2017 Mar 1;24(3):312-326.
  29. Skin autofluorescence and peripheral neuropathy four years later in type 1 diabetes. Rajaobelina K. et al. Diabetes Metab Res Rev. 2017 Feb;33(2).
  30. Relationship between advanced glycation end-product accumulation and low skeletal muscle mass in Japanese men and women. Kato M. et al. Geriatr Gerontol Int. 2017 May;17(5):785-790.